Tomato Bushy Stunt Virus (TBSV)
Unknown Year, 7 1/4" x 6 3/4"
Geis illustrates the structure of tomato bushy stunt virus, which was first revealed by X-ray crystallography in 1978 (Harrison et al., 1978).
Used with permission from the Howard Hughes Medical Institute (www.hhmi.org). All rights reserved.
Related PDB Entry: 2TBV
Experimental Structure Citation
Hopper, P., Harrison, S. C., & Sauer, R. T. (1984). Structure of tomato bushy stunt virus: V. Coat protein sequence determination and its structural implications. J. Mol. Biol. 177, 701-713.
About Tomato Bushy Stunt Virus
Tomato bushy stunt virus (TBSV) is a tombusvirus that leads to stunting, leaf mottling, and deformation or absence of fruit in plant hosts (Wagner et al., 2007). TBSV is an isometric virus with triangulation number equal to 3, which indicates that the virus is composed of 180 coat protein (a triangulation number of 1 corresponds to 60 subunits of single coat protein). Three different types of polypeptide chains are present in TBSV: A (red in static rendition), B (blue in static rendition), and C (green in static rendition). The 180 TBSV proteins encapsulate a single-stranded RNA, which consists of about 4,800 nucleotides.
Text References
Caspar, D. L. D. & Klug, A. (1962). Physical principles in the construction of regular viruses. Cold Spring Harbor Symp. 27, 1-24.
Timmins, P. A., Wild, D., & Witz, J. (1994). The three-dimensional distribution of RNA and protein in the interior of tomato bushy stunt virus: a neutron low-resolution single-crystal diffraction study. Structure, 2, 1191-1201.
Wagner, E.K., Hewlett, M.J., Bloom, D. C., & Camerini, D. (2007). Basic Virology. John Wiley & Sons. 3, 268. ISBN: 9781405147156.
Initial Structure Determination References
Harrison, S. C., Olson, A. J., Schutt, C. E., Winkler, F. K., & Bricogne, G. (1978). Tomato bushy stunt virus at 2.9 Å resolution. Nature (London), 276, 386.
