7. Myc-Max-DNA

Geis paints Myc-Max at the bottom of the painting in a faint blue outline. Myc-Max does not interact directly with TBP, but is a factor in transcriptional activation.

1. apo-TBP
2. TBP-DNA
3. TBP-TFIID-DNA
4. TBP-TFIIB-DNA
5. TBP-TFIIA-DNA
6. RNAP2
7. Myc-Max-DNA
8. HNF-3γ/DNA
Back to main TATA-Binding Protein (TBP) Page

Used with permission from the Howard Hughes Medical Institute (www.hhmi.org). All rights reserved.

Related PDB Entry: 1NKP

Experimental Structure Citation

Nair, S. K. & Burley, S. K. (2003). X-ray structures of Myc-Max and Mad-Max recognizing DNA: Molecular bases of regulation by proto-oncogenic transcription factors. Cell, 112, 193-205.

About Myc-Max-DNA

Myc-Max is a transcription factor complex that binds to DNA and functions in transcriptional activation. The Myc protein must first form a heterodimer with Max protein that can then bind to DNA. The Myc protein has a critical role in controlling cell growth.